Quantitative proteomics: A strategic ally to map protein interaction networks
نویسندگان
چکیده
منابع مشابه
Quantitative proteomics: A strategic ally to map protein interaction networks.
Many physiological processes are regulated by dynamic protein interaction networks whose characterization provides valuable information on cell biology. Several strategies can be used to analyze protein-protein interactions. Among them, affinity purification combined with mass spectrometry (AP-MS) is arguably the most widely employed technique, not only owing to its high throughput and sensitiv...
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Large-scale affinity purification and mass spectrometry studies have played important roles in the assembly and analysis of comprehensive protein interaction networks for lower eukaryotes. However, the development of such networks for human proteins has been slowed by the high cost and significant technical challenges associated with systematic studies of protein interactions. To address this c...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 2012
ISSN: 1521-6543
DOI: 10.1002/iub.1081